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Epistasis is the interaction between genes that influences a phenotype. Genes can either mask each other so that one is considered “dominant” or they can combine to produce a new trait. It is the conditional。

Epistasis occepitasiurs when the phenotype expression of one gene is influenced by another gene. Example: Gene A must be present for Gene B to express a certain trait. Example: The coat color in mice is a classic example。

We assessed the functional impact of the epistasis signals across a range of functional/-omics datasets identifying significant single-variant eQTLs across brain tissues,。

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